Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate.
نویسندگان
چکیده
The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
منابع مشابه
Effect of dietary γ-aminobutyric acid on performance parameters and some plasma metabolites in Cherry Valley ducks under high ambient temperature
Gamma aminobutyric acid (GABA) is one of the inhibitory neurotransmitters that may have the ability torelieve the intensity of stress. Heat stress remains a major threat for duck production in summer in most areas of China. The current study was conducted to investigate the effect of dietary GABA on performanceparameters and plasma metabolites of heat exposed ducks. Two thousand Cherry Valley d...
متن کاملSeed storage at elevated partial pressure of oxygen, a fast method for analysing seed ageing under dry conditions
BACKGROUND AND AIMS Despite differences in physiology between dry and relative moist seeds, seed ageing tests most often use a temperature and seed moisture level that are higher than during dry storage used in commercial practice and gene banks. This study aimed to test whether seed ageing under dry conditions can be accelerated by storing under high-pressure oxygen. methods: Dry barley (Horde...
متن کاملDehydration of Lactose Monohydrate: Analytical and Physical Characterization
Dehydration of hydrates of pharmaceutical inactive/active ingredients (pharmaceutical hydrates) may easily occur during storage or manufacturing. Loss of water may have little effect on the crystal lattice, produce less hydrated forms or possibly amorphous form. Characterizing the effects of water loss on crystal hydrate forms is important for understanding the behavior of hydrates throughout t...
متن کاملInvestigation of the Hydrate Formation Equilibrium Conditions of Natural Gas
One of the main problems in oil recovery via the gas injection is the formation of hydrates in thelines. In order to prevent the formation of hydrate in these lines, which leads to the blockage andsometimes explosion, at first, the equilibrium formation conditions must be determined and then toprevent its formation by changing the thermodynamic conditions or by adding the inhibitors. In thisres...
متن کاملStructure and physical stability of hydrates and thermotropic mesophase of calcium benzoate.
The aim of this study is to investigate the hydration and the dehydration processes of calcium benzoate hydrates (trihydrate and monohydrate), thermotropic mesophases (dehydrated mesophase and lyophilized mesophase) and amorphous state, and the influence of their molecular order on those processes. X-ray analysis revealed that trihydrate has a planar structure composed of two types of planes-on...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 50 15 شماره
صفحات -
تاریخ انتشار 2014